Inhibition of osteoblastic bone formation by nuclear factor-kappaB

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Inhibition of osteoblastic bone formation by nuclear factor-kappaB. This repressed the NF-B-dependent transcription of nuclear factor of activated T cells, cytoplasmic 1 (NFATc1), an essential regulator of osteoclastogenesis. These findings suggest that an Ifrd1/NF-B/NFATc1 axis plays a pivotal role in bone remodeling and represents a therapeutic target for bone diseases. INTRODUCTION Interferon-related developmental regulator 1 […]


During experiments, larvae were kept in HEPES buffered (pH 7

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During experiments, larvae were kept in HEPES buffered (pH 7.2) E3 press while Ononetin described (Kimmel et al., 1995). differential temporal involvement of microglia and peripheral macrophages in clearance of lifeless cells in the brain, exposing the chronological sequence of events in neuroinflammatory resolution. Amazingly, recruited phagocytes undergo cell death and are engulfed by microglia. […]