Secondary antibodies were Amersham ECL donkey anti-rabbit or sheep anti-mouse horseradish peroxidase (HRP)-linked IgG antibody (both GE Healthcare UK Limited, Little Chalfont, UK)

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Secondary antibodies were Amersham ECL donkey anti-rabbit or sheep anti-mouse horseradish peroxidase (HRP)-linked IgG antibody (both GE Healthcare UK Limited, Little Chalfont, UK). growth medium only or induced to osteogenically differentiate by the addition of health supplements (-glycerophosphate, ascorbic acid, dexamethasone, and 1,25-dihydroxyvitamin D3). The activation of and requirement for PI3K/Akt signaling in MSC osteogenesis […]


In particular, p53 mainly mediates prosenescence signals that are derived via oncogene activation, telomere dysfunction, DNA damage, and reactive oxygen species [9]

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In particular, p53 mainly mediates prosenescence signals that are derived via oncogene activation, telomere dysfunction, DNA damage, and reactive oxygen species [9]. dickkopf-1 (an antagonist of the Wnt coreceptor) and -catenin siRNA transfection promotes senescence in MSCs. Interestingly, the magnitude of the response to enhanced Wnt3a/-catenin signaling appears to depend on the senescent state during […]