We hypothesized that IP3-induced Ca2+ release during the initial phase would activate Pyk2
We hypothesized that IP3-induced Ca2+ release during the initial phase would activate Pyk2. Both phosphorylation of Pyk2 and FAK leads to phosphorylation of paxillin at Tyr118 and association of phosphorylated paxillin with the GEF proteins p21-activated kinase (PAK) interacting exchange factor , ( and PIX) and DOCK 180. These GEF proteins stimulate Cdc42 leading to […]
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