However, the use of minichromosomes reconstituted in aXenopusegg extract precluded determination of binding dynamics in the context of the nucleosomal dyad, and a direct role for MeCP2 in competitive exclusion of H1 was not established
However, the use of minichromosomes reconstituted in aXenopusegg extract precluded determination of binding dynamics in the context of the nucleosomal dyad, and a direct role for MeCP2 in competitive exclusion of H1 was not established. component in transcriptional regulation, with methylation generally leading to repression of nearby genes (6). However, the mechanism by which the […]
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