Our study explores the risk factors of HBV infection for vaccinated and unvaccinated married people aiming to examine (1) the prevalence of HBV among married individuals in 2006 and 2014; (2) the risk factors of HBV infection, especially infected spouses, in vaccinated and unvaccinated groups; and (3) changes in prevalence rate, risk factors, and relative risk (RR) value of HBV infection among vaccinated and unvaccinated individuals between 2006 and 2014

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Our study explores the risk factors of HBV infection for vaccinated and unvaccinated married people aiming to examine (1) the prevalence of HBV among married individuals in 2006 and 2014; (2) the risk factors of HBV infection, especially infected spouses, in vaccinated and unvaccinated groups; and (3) changes in prevalence rate, risk factors, and relative risk (RR) value of HBV infection among vaccinated and unvaccinated individuals between 2006 and 2014. Materials and methods Study design A cross-sectional study was designed to examine the risk factors of HBV in married individuals. 14.18% in 2014, respectively. For vaccinated individuals, age was significantly correlated with anti-HBc in 2014 (40 age 50 versus age 30, relative risk (RR) = 3.03, 95% confidence interval (95%CI) = 1.04C8.84). Gender [male versus female, RR = 0.60, 95%CI = 0.36C1.00 (2006); RR = 0.71, 95%CI = 0.52C0.97 (2014)] and age (in 2006) were found Cariporide to be significantly associated with single anti-HBs. For unvaccinated individuals, HBsAg positivity was statistically significant correlated with gender [RR = 1.47, 95%CI = 1.04C2.06, in 2006], residence (urban versus rural, RR = 0.40, 95%CI = 0.24C0.67, in 2006; RR = 0.58, 95%CI = 0.34C0.99, in 2014), sharing syringes [RR = 3.75, 95%CI = 1.33C10.63 (in 2006); RR = 2.07, 95%CI = 1.26C3.41 (in 2014)], infected wives (RR = 1.97, 95%CI = 1.28C3.05, in 2006), and infected husbands (RR = 2.19, 95%CI = 1.25C3.82, in 2006). Anti-HBc positivity was significantly associated with gender [RR = 1.19, 95%CI = 1.10C1.30 (in 2006); RR = 1.24, 95%CI = 1.09C1.40 (in 2014)], age (in 2006 and 2014), endoscopic medicine treatment [RR = 1.16, 95%CI = 1.03C1.32 (in 2006), RR = 1.21, 95%CI = 1.01C1.45 (in 2014)], sharing syringes (RR = 1.43, 95%CI = 1.25C1.64, in 2014), body piercing (RR = 0.84, 95%CI = 0.75C0.93, in 2006), infected wives (RR = 1.32, 95%CI = 1.18C1.47, in 2006), and infected husbands (RR = 1.39, 95%CI = 1.22C1.59, in 2006). Anti-HBs positivity was associated with age (in 2006 Cariporide and 2014). Conclusions: Prevalence of HBV infection was lower in 2014 than in 2006 according to HBsAg and anti-HBc positivity. Unvaccinated individuals faced much more risk of HBV infection than those of vaccinated. strong class=”kwd-title” KEYWORDS: Hepatitis B vaccination, married people, risk factor, horizontal transmission, seroprevalence Introduction As one of the most serious public health issues worldwide, hepatitis B virus (HBV) infection could cause lifelong chronic HBV carrier or lead to cirrhosis or hepatocellular carcinoma (HCC).1,2 It was estimated that HBV had affected at least 257 million people worldwide,3 and about 90 million people suffered from HBV-related diseases in China.4 Liver cancer and other chronic diseases caused by HBV could be effectively prevented by HBV vaccine. In order to control the ascending tendency of HBV infection, the World Health Organization (WHO) encouraged all member countries to popularize HBV vaccine immunization.3 As one of the member countries with high HBV prevalence, China responded to WHO strategy actively by recommending HBV vaccine immunization for newborns in 1992 and took HBV vaccination into Expanded Program on Immunization (EPI) in 2002. HBV vaccination for newborns was free of charge after 2005.5 China also launched a HBV vaccination project for adolescents and adults since 2006.6 To realize the goal of better controlling hepatitis B transmission, China government even encouraged some conditional districts to take effective measures MGC45931 promoting adult hepatitis B vaccine. For example, free vaccination of adult hepatitis B vaccine was executed in the Chaoyang District of Cariporide Beijing since 2017.7 Nevertheless, the number of HBV-infected people was growing year by year.8 HBV had threatened public health and induced serious social panic in China.9,10 It is well known that risk behaviors such as dialysis, blood transfusion, or tattooing were Cariporide shown to be related to HBV infection in earlier studies.11C13 In addition, HBV was vertically transmitted from mother to child or horizontally transmitted by transfusion of HBV-infected blood or body fluid.14 Sexual contact is one of the most common routes of horizontal HBV transmission.15 Similarly, intimate behaviors of spouses such as kissing and sharing things with each other may also lead to HBV infection.16 It still remains unclear that whether marriage is a risk factor of HBV infection or not for those who have been vaccinated. Although a study in Gambia reported that marriage was not a risk factor of HBV infection for.