Anti-ICAM/-Gal NCs are targeted to and remain in tissue:(a) Mice injected with anti-ICAM/125I–Gal NCs were perfused at 30 minutes
Anti-ICAM/-Gal NCs are targeted to and remain in tissue:(a) Mice injected with anti-ICAM/125I–Gal NCs were perfused at 30 minutes. lysosomal transport of anti-ICAM/-Gal NCs in macro- and micro-vascular ECs, and a marked enhancement of Gb3 degradation. Therefore, ICAM-1-targeting strategy may help improve the efficacy of therapeutic enzymes for Fabry disease. Keywords: Vascular endothelium, Fabry disease, […]
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