These models make use of the evolutionarily conserved essential mechanisms important in CNS safety, which operate in mammals and nonvertebrate organisms (Bundgaard and Abbott 2008; DeSalvo et al
These models make use of the evolutionarily conserved essential mechanisms important in CNS safety, which operate in mammals and nonvertebrate organisms (Bundgaard and Abbott 2008; DeSalvo et al. candidates. In addition, the MDR1-MDCK cells possessed Pgp transporter activity markedly greater than in vivo (Mahar Doan et al. 2002; Feng et al. 2008), making the prediction […]
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