non-specific IgM binding to erythrocytes contaminated by parasites expressing the PfEMP1 protein VAR2CSA (involved with placental malaria pathogenesis and defensive immunity) blocked following particular binding of individual monoclonal IgG towards the Duffy binding-like (DBL) domains DBL3X and DBL5 of the PfEMP1 variant
non-specific IgM binding to erythrocytes contaminated by parasites expressing the PfEMP1 protein VAR2CSA (involved with placental malaria pathogenesis and defensive immunity) blocked following particular binding of individual monoclonal IgG towards the Duffy binding-like (DBL) domains DBL3X and DBL5 of the PfEMP1 variant. GW284543 binds outside these domains and will inhibit IE adhesion to the precise […]
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