IGF-1R can develop heterotrimers and heterodimers with HER2 and HER3 in breasts cancers cells resistant to trastuzumab
IGF-1R can develop heterotrimers and heterodimers with HER2 and HER3 in breasts cancers cells resistant to trastuzumab.45,46 Similarly, increased degrees of EpoR, EpHA2 and RTK MET can activate P13K/Akt/mTOR by getting together with other members from the ErbB family or through activation of intracellular kinases.46C48 Level of resistance to cetuximab (anti-EGFR TC21 therapy) The epidermal […]
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