In particular, p53 mainly mediates prosenescence signals that are derived via oncogene activation, telomere dysfunction, DNA damage, and reactive oxygen species [9]

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In particular, p53 mainly mediates prosenescence signals that are derived via oncogene activation, telomere dysfunction, DNA damage, and reactive oxygen species [9]. dickkopf-1 (an antagonist of the Wnt coreceptor) and -catenin siRNA transfection promotes senescence in MSCs. Interestingly, the magnitude of the response to enhanced Wnt3a/-catenin signaling appears to depend on the senescent state during […]