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3. the activity of [T315I]Abl oncogene. The gene encodes persistently high levels of cytoplasmic and constitutively active BCR-ABL tyrosine kinase, which is usually detected in >90% of CML patients and 25% of adult patients with acute lymphocytic leukemia (ALL)3. Animal studies also provide evidence to support BCR-ABL Derazantinib (ARQ-087) as the oncogenic cause of CML […]