(B) Aftereffect of PFK15 about IKK and IB phosphorylation

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(B) Aftereffect of PFK15 about IKK and IB phosphorylation. PFKFB3 inhibition reduced the manifestation of IL\8, IL\6, CXCL\10 and CCL\2 as well as the proliferation, invasion and migration of RA FLSs. PFK15 suppressed TNF\\induced activation of NF\B and p38, ERK and JNK MAPK indicators in RA FLSs. PFK15 treatment suppressed glucose uptake and lactate secretion […]