These data suggest, CD8+ T cells may play an overall regulatory role in the context of immune thrombocytopenia and enhance the therapeutic effect of DEX treatment

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These data suggest, CD8+ T cells may play an overall regulatory role in the context of immune thrombocytopenia and enhance the therapeutic effect of DEX treatment. dexamethasone (DEX) treatment selectively expanded CD8+ Tregs while decreasing CTLs. In vitro coculture studies revealed CD8+ Tregs suppressed CD4+ and CD19+ proliferation, platelet-associated immunoglobulin G generation, CTL cytotoxicity, platelet […]