Structural Optimization of Thiol-Based Inhibitors of Glutamate Carboxypeptidase II by Adjustment from the P1′ Side Chain

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Structural Optimization of Thiol-Based Inhibitors of Glutamate Carboxypeptidase II by Adjustment from the P1′ Side Chain. that GCPII is more tolerant of different scaffolds presented with the thiol-based materials than various other series structurally. For instance, strenuous SAR research of thiol-based GCPII inhibitors resulted in the breakthrough of 3-(2-mercaptoethyl)-biphenyl-2,3-dicarboxylic acidity 2 (E2072) filled with a […]